We are also developing strategies to independently and reversibly modulate the biophysical and biochemical properties of cell-laden hydrogels in order to delineate the influence of various immobilized and soluble extracellular factors on pancreactic cancer cell fate processes, including drug resistance. Get the latest business insights from Dun & Bradstreet. Specifically, we are developing innovative dynamic desmoplasia-mimetic hydrogel matrix to encapsulate pancreatic cancer cells (e.g., PANC-1, COLO-357, and ASPC1) and study their growth, morphogenesis, and epithelial-mesenchymal transition (EMT). Find company research, competitor information, contact details & financial data for ISMARTPHOTO (MALAYSIA) SDN. Toward this end, we are interested in developing synthetic hydrogels that can be reversibly stiffened or softened in a range relevant to pancreatic cancer cells. Our central hypothesis in this research project is that a synthetic tumor niche with dynamically and modularly adaptable properties can be used to elucidate the influence of extracellular matrix (ECM) cues on the growth, morphogenesis, and drug efficacy in PDAC cells. Although a few studies have explored the utility of 3D matrices, such as Matrigel, for pancreatic cancer research, the commercially available matrices are mechanically weak and contain ill-defined and un-controllable biochemical components that may confound the experimental results. Dantian Eight (or six) vessels: Dumai Renmai 12 channels. The stages of each major realm has 3 levels, stated as 'First Sky', ' Second Sky' and 'Third Sky'. It is also believed that desmoplasia communicates with pancreatic cancer cells to promote tumor progression and to hinder drug penetration and efficacy. 4.8 (420 ratings) 1 title per month from Audible's entire catalog of best sellers, and new releases. 2D cell culture techniques are also inadequate in the study of tumor cells, which are highly influenced by the stromal tissues (i.e., desmoplasia, dense extracellular matrices deposited by activated pancreatic stellate cells) found in three-dimensional (3D) tumors. The ultrahigh stiffness of a 2D surface not only un-naturally polarizes the attached cells, but also causes the cells to behave differently due to abnormal mechano-sensing. To date, most in vitro pancreatic cancer studies have been conducted on two dimensional (2D) tissue-culture plastic dishes (TCP) that are unnaturally stiff (E > 1 GPa). Community-Academic Collaborative Pilot Research Award.Research Program Support for Pilot Projects.Hematopoiesis & Hematologic Malignancies.Experimental & Developmental Therapeutics.

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